منابع مشابه
Force spectroscopy of chromatin fibers: extracting energetics and structural information from Monte Carlo simulations.
The folding of the nucleosome chain into a chromatin fiber is a central factor for controlling the DNA access of protein factors involved in transcription, DNA replication and repair. Force spectroscopy experiments with chromatin fibers are ideally suited to dissect the interactions that drive this process, and to probe the underlying fiber conformation. However, the interpretation of the exper...
متن کاملDynamics of the nucleosome and chromatin fiber studied by single molecule spectroscopy and computer simulations
We present recent studies on the structure and dynamics of monoand oligonucleosomes, using fluorescence correlation spectroscopy and fluorescence resonance energy transfer (FRET). The effect of salt concentration, linker histone H1 and histone acetylation on the structure of monoand trinucleosomes reconstituted on nucleosome positioning sequences was investigated by FRET in bulk solution and on...
متن کاملChromatin fibers, one-at-a-time.
Eukaryotic DNA is presented to the enzymatic machineries that use DNA as a template in the form of chromatin fibers. At the first level of organization, DNA is wrapped around histone octamers to form nucleosomal particles that are connected with stretches of linker DNA; this beads-on-a-string structure folds further to reach a very compact state in the nucleus. Chromatin structure is in constan...
متن کاملinvestigation of thermal comfort properties of woven sport fabric using blend of estabragh fibers
امروزه لباس در نظر ورزشکاران و کسانی که برای اوقات فراغت خود و یا برای رسیدن به اندامی متعادل، ورزش می کنند؛ بسیار با اهمیت است. احساس مطلوب از لباس در زمره خصوصیات راحتی پوشش می باشد. خصوصیات انتقال رطوبت لباس، در ارزیابی راحتی حسی و حرارتی منسوجات تولید شده از آن ها بسیار مهم است. هدف از این تحقیق، معرفی پارچه جدید است که متشکل از الیاف استبرق با خواص منحصر به فرد می باشد. استبرق لیف طبیعی تو...
Computer simulations as experiments
Whereas computer simulations involve no direct physical interaction between the machine they are run on and the physical systems they are used to investigate, they are often used as experiments and yield data about these systems. It is commonly argued that they do so because they are implemented on physical machines. We claim that physicality is not necessary for their representational and pred...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.180